Mikulov and its surroundings is a traditional wine centre. The geographical position, the climate and the varied soil of the Mikulov wine region with the limestone slopes of the Pálava Hills affect the unique character of the local wine. This was already discovered by Ancient Romans, who considered the Pálava region ideal for vine growing. The major wine centres of the Mikulov wine region include Mikulov in the first place, and further Valtice, Dolní Dunajovice, Novosedly, Perná, Sedlec, Pavlov, Dolní Věstonice, Horní Věstonice and Brod nad Dyjí.

Another popular variety is Rhine Riesling, coming from the Rhineland and belongs to the serotinous varieties. The best wine is achieved by over-ripening of the grapes. The characteristic features of Rhine Riesling include its typical yellow-green colour and fine aroma with a hint of linden blossom. Mature wine is peppery and spicy.

Rhine Riesling lends its properties to the new variety called Aurelius. The variety was cultivated in the Perná cultivation station. Its typical features include full, strong taste and fine characteristic quince and linden aroma. The municipality of Perná is also the origin of another new variety, Pálava, appreciated even by leading French wine specialists. The variety yields full wine of golden colour with lower acid content and rose and vanilla aroma.

The varied family of white wines from the region further includes Ruland White or Chardonnay, originating from Burgundy. Both varieties like the calcic soil. While Ruland White is characterised by fine flowery aroma combined with pear, bread rind and hazelnut aroma of the mature wine, the mature Chardonnay smells of honey. The latter wine is characterised with full, typical taste and aroma, spiciness and higher intensity of aromatic substances.

Gravel soil is also good for blue vine varieties such as Svatovavřinecké, the most popular variety for Moravian red wine, preferred for its dark red colour and strong wild cherry or black currant aroma. Frankovka, typical for northern vineyards, is characterised with pleasant spiciness combined with fruit flavour, while Blue Portugal, with fewer tannin, is lighter and smells of flowers.